Generally, the spatial distribution of hippocampal connectivity among healthy controls showed strong and focused signal bilaterally within the body of the hippocampi (see Figure 4a). Controls also demonstrated connectivity in the septal and subthalamic neuclei. While the hippocampus appeared to have connectivity with bilateral parahippocampal gyri, the majority of correlated signal among controls occurred in the anterior medial temporal lobes. In contrast, patients demonstrated more abundant connectivity with the parahippocampal gyrus and posterior cingulate, as well as more diffuse connectivity in the temporal and frontal lobes, basal forebrain, and subthalamic nuclei than controls. Furthermore, in areas of bilateral hippocampal connectivity, patients demonstrated weaker contralateral connectivity than controls (see Figure 4b). Healthy right hippocampal connectivity showed a similar pattern of connectivity as the left hippocampus.
