GAWMerge was developed within the DNANexus computing environment (https://www.dnanexus.com/) and the BioData Catalyst ecosystem37. The protocol within the DNANexus computing environment used docker images, which have been packaged together into DNANexus applications. The BioData Catalyst ecosystem37 protocol was implemented in the common workflow language (CWL); therefore, it is interoperable in other computing ecosystems. Both implemented workflows are built using the same docker images of the underlying software programs (https://github.com/RTIInternational/biocloud_docker_tools and https://hub.docker.com/u/rtibiocloud). The protocol has been written to easily adapt to plink or vcf formats of the genotype files, therefore either are acceptable. The BioData Catalyst workflow leverages key services, tools, and workflows available within the ecosystem including BioData Catalyst Powered by Gen3, BioData Catalyst Powered by PIC-SURE, and BioData Catalyst Powered by Seven Bridges. These tools make discovery of data for use as public controls easy with their easy-to-use web interface.
