Several intronic SNPs were associated with response to alcohol in Native Americans (NA), which is correlated with less susceptibility to dependence (Ehlers et al. 2008). In a study of methamphetamine dependence/psychosis (Ide et al. 2004; Ide et al. 2006), 16 variants in the 5′ regulatory region and intron 1 were studied in Japanese subjects. Association was found with SNP rs2075572 (IVS2+691G>C).
