Many top cerebellar cisSNPs also associate with non–CNS diseases/traits (Supplementary Table 9 in Dataset S1). IRF5 cisSNP rs4728142 is associated with both cerebellar IRF5 levels and risk of systemic lupus erythematosus (SLE) [35]. Previously, IRF variants were shown to influence IRF splicing and expression as well as SLE risk [36], [37]. Interestingly, rs4728142 is also associated with ulcerative colitis (UC) [38] where both IRF5 and TNPO3 are reported as candidate genes. Given its influence on IRF5, but not TNPO3 expression levels, rs4728142 most likely marks IRF5, but not TNPO3 as the candidate UC risk gene.
