two SNPs. However, because of the high correlation between these SNPs, joint regression modeling was unable to discern the independent effect of each. Follow-up analyses on the top SNP (rs2072661) indicated a role in the time to relapse within the 6-month follow-up period and an impact on withdrawal symptoms at TQD. Investigation of a functionally significant SNP within CHRNA4, a biologically relevant interaction since the α4β2 nAChRs form a common subtype, demonstrated a suggestive, albeit non-significant, interaction.
