In our association analysis based on the AD factor score, we observed 60 SNPs with p<10-5 in the EA sample and 81 SNPs showing p<10-5 in the AA sample. In both samples, the top SNPs were located in intergenic regions: in the EA sample rs2876950 (p=7.52×10-6) was 148kb from the nearest gene, COBL (cordon bleu homolog), and in the AA sample, rs6777876 (p=4.0×10-7) was 68kb from a predicted gene, C3orf31, and 277kb from SYN2 (synapsin II). Although many SNPs were located in intergenic regions, both samples showed several SNPs to be located within or close to genes. Using a cutoff of p<10-4, we observed 249 SNPs lying either in a gene or located within 100kb of a gene in the EA sample and 438 such SNPs in the AA sample. These SNPs are listed in the supplementary Tables A1 and A2.
