Two hiPSC clones were established from each of two female schizophrenic patients: SA001-1D2, SA001-3B1 from SA001 (aged 37 years old), and KO001-19 and KO001-25 from KO001 (aged 30 years old; Supplementary Figure 1a). The clinical histories of the patients have been described in our previous reports.20, 21 The control hiPSC lines 201B7 and YA9 were generated from a 36-year-old Caucasian female22, 23 (Supplementary Figure 1a). The remaining control hiPSC lines WD39 and KA23 were generated from a 16-year-old Japanese female and a 40-year-old Japanese male,22, 24 respectively (Supplementary Figure 1a). The control and patient human dermal fibroblasts were reprogrammed with retrovirus expressing the transcription factors OCT4, SOX2, KLF4 and C-MYC. The maintenance of human dermal fibroblasts, retroviral preparation, infection methods, hiPSC culturing and characterization of established cells were performed as described previously.23
