Chunk #43 — Methods and results — Testing for significance of gene-environment interaction effects using the reparameterized equation — Extensions of the equation

Source

Testing for measured gene-environment interaction: problems with the use of cross-product terms and a regression model reparameterization solution.

Embedded

yes

Text

Although it is not advisable to test for more complex interactions without an explicit a priori rationale, due to the loss of power when estimating an increasing number of parameters and the possibility of collinearity problems, we note that it is possible to test for them when circumstances warrant.