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Chunk #26 — EPs and environmental risk factors

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Endophenotype: a conceptual analysis.
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To make matters more complex, it is perfectly possible that certain EPs reflect both the genetic and the environmental risk factors for a disorder. For example, the cognitive abnormalities considered to be an EP for schizophrenia are likely influenced both by genetic risk factors for schizophrenia, as well as environmental risk factors such as famine,20 in utero viral infections21 or birth complications.22