Change measured in the 15 tissue ROIs revealed similar patterns regardless of registration method (Figure 4). For the sequential method, significant declines in volumes were present in five regions: lateral frontal (p=.0001), medial frontal (p=.0002), anterior cingulate (p=.01), precuneus (p=.0006), and parietal (p=.0001) cortices; the temporal cortex showed a trend (p=.02). For the independent method, significant declines in volumes were present in four regions: lateral frontal (p=.0005), medial frontal (p=.0063), precuneus (p=.0014), and parietal cortices (p=.0011).
