Subsequently, all genes from the gene-based test with a P-value<0.01 were included in a pathway analysis using the Ingenuity Pathway analysis program (Ingenuity Systems, Redwood City, CA, USA, release IPA 6.0). By performing these pathway analyses we tried to identify whether the genes most associated with the personality scales were more prevalent in any known biological or canonical pathway than would be expected by chance. The alpha level was set at 0.0125 (0.05/4 personality scales) and significance of individual pathways was corrected for multiple testing by the Benjamini–Hochberg procedure as implemented in Ingenuity. The pathway analysis was performed on the results from the gene-based test of the meta-analysis results.
