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Chunk #39 — RESULTS — miR-34a dysregulation alters differentiation of human iPSC-derived neurons

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Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder.
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a highly connected interaction network (Figures 4B and S6; See Supplemental text for details). Together, these findings support the hypothesis that elevation of miR-34a levels coordinately affects functionally connected pathways important for brain development and that dysregulation of miR-34a may be sufficient to affect the expression of multiple candidate BD susceptibility genes and genes critical to human neurodevelopment.