It is important to note that, among statistically significant findings, the comparison between the odds-ratios of the OR and the AOR models revealed minor differences between the models, providing strong evidence of a common or shared liability between the substances. Significant odds-ratios from the OR model that are no longer significant in the AOR model indicate that these associations may have been driven by the other substances. Lastly, the rank ordering of the magnitude of the substance-specific risk based on adolescent drug use was greatest for tobacco (5.89), followed by marijuana (2.91) and alcohol (1.93).