simulationsGWAS populationTotal No. PRS variants (p < 0.01)No. causalNo. in LD with a causal variantr2 > 0.8r2 > 0.6r2 > 0.4r2 > 0.2EuropeanLD in Europeans1,552 (1,134–1,920)18 (10–26)27 (16–40)32 (22–44)39 (25–55)58 (38–80)LD in Africans20 (9–36)25 (16–42)34 (24–54)53 (35–70)AfricanLD in Europeans5,269 (4,462–6,071)28 (18–40)94 (67–122)132 (95–171)183 (123–238)280 (202–364)LD in Africans37 (26–48)48 (34–61)67 (50–89)127 (81–170)Fixed-effects meta-analysisLD in Europeans92 (38–197)12 (5–22)15 (6–26)17 (6–28)21 (9–39)29 (16–47)LD in Africans13 (6–21)14 (6–25)17 (9–29)24 (10–43)The set of PRS variants from each GWAS and the fixed-effects meta-analysis were selected by p value thresholding (p < 0.01) and clumping (r2 < 0.2) across the 50 simulations. Each PRS variant was compared to the causal set of variants (m = 1,000) within each simulation to determine the direct overlap between the two sets and the LD r2 between the PRS variant and every causal variant within a 1,000 kb window. The total number of selected PRS variants that tag at least one causal variant at r2 greater than 0.8, 0.6, 0.4, or 0.2 is listed in the table. The number of variants is reported as the average and range (low–high) across the 50 simulations.
