Chunk #60 — Protein Kinase C
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PKCs require phosphorylation by phosphoinositide-dependent kinase 1 (PDK1) and subsequent autophosphorylation in the catalytic domain to be fully active. For conventional PKCs, this is thought to be a constitutive process, whereas for novel and atypical PKCs, there is a pool of unprocessed enzyme present that can be phosphorylated by PDK1 and recruited into an activatable pool.156