Additional insights may come from the divergence between the previous findings of significantly increased coherence between anterior cingulate cortex and the DMN in schizophrenia during an auditory oddball task (Garrity et al., 2007) and our findings of significantly reduced coherence in the same region for the same disorder during rest. It is possible that schizophrenia patients recruit the anterior cingulate cortex into the DMN too well during task performance and not enough during rest, i.e. they are unable to “turn it off” during tasks and to “turn it on” at rest. This hypothesis can be tested in studies of the same subjects’ DMN during rest and tasks of varying difficulty.
