The Schizophrenia Exome Sequencing Meta-Analysis (SCHEMA) consortium (companion paper) identified 32 genes with damaging ultra-rare mutations associated with schizophrenia (FDR<0.05), including 10 at exome-wide significance. We found both sets of genes were enriched for common variant associations, as were more weakly associated SCHEMA genes down to uncorrected P<0.001 (Figure 2a, Supplementary Tables 20, 21). Moreover, within associated loci, protein coding genes containing one or more FINEMAP credible SNPs were enriched for SCHEMA genes relative to other protein-coding genes (Figure 2b; Supplementary Table 21). There are rare variant overlaps in liability to schizophrenia, autism spectrum disorder (ASD) and developmental disorder (DD)8,30,31. We tested for and found that genes in which rare variants increase risk of ASD and DD32,33 are also enriched for schizophrenia common variant associations. Moreover, they are also enriched among genes containing FINEMAP credible SNPs (Figure 2 Supplementary Tables 20, 21).
