One region on chromosome 4 reached genome-wide significance for SRE-5 (P-value=4.18E-05) (Table 2; Figure 1). The most significant blocks in this region were between 24,377,777 bp and 24,512,590 bp and were supported by both the COGA and NIAAA cohorts. The estimate of effect size is larger in NIAAA than in COGA due to the proportion of study participants with higher SRE scores and larger variation in the NIAAA sample. Individuals carrying African ancestry blocks in this region had higher SRE scores (BETA=0.21, SE=0.05), i.e., lower the response to alcohol. No other region reached genome-wide significance for other phenotypes (Supplement Figures 1A, 1B, 1C).
