Health and social consequences of the COVID-19 pandemic are not clearly known. This pandemic may last several months and involves new way of tackle with addictions. Overall, patients with addictions have an increased risk of infections and developing severe forms of them. There may be a bilateral impact between each substance use disorder and SARS-Cov2 (for review of the bilateral impact, see Table 1 ). Individuals with addictions are at higher risk at each step of the pandemic, especially those with opioid use disorder.Table 1The relationship between COVID-19 and substance use during and after lockdown.Table 1AlcoholTobaccoCannabisOpiatesBefore and during lockdownImpact of substance use on COVID-19IncreaseIncrease or decreaseIncreaseIncreaseImpact of substance use on COVID-19 course and prognosisLikely to worsenProbably worsenProbably worsenWorsenImpact of lockdown on substance useLikely to increaseDepend on availabilityDepend on availabilityDepend on availabilityImpact of lockdown on substance use careLikely to decreaseLikely to decrease, depend on drugstore availabilityLikely to decreaseLikely to decrease, depend on OST availabilityAfter lockdownImpact of lockdown cessation on substance use related issuesIncreaseIncreaseNAIncrease in overdoses is likely, due to decreased toleranceAbbreviations: NA, data are not available; OST, Opioid substitution therapy.
