and nine PRS thresholds was applied to all findings, requiring a p value < 0.003 to meet criteria for statistical significance. Cannabis use and CUD were moderately correlated (r2: 0.40, p < 0.001); PRS across varying thresholds were only modestly correlated (r2 ranged from 0.04 to 0.07). To further reduce the multiple test burden, moderation analyses were only conducted with those PRS for which a significant main effect on cannabis use and/or CUD symptom count (CUDsx) was observed. When significant main effects of the PRS were observed, we tested for multiplicative interactions with trauma exposure and frequency of religious service attendance. When significant main effects of the PRS were observed, we tested for multiplicative interactions with trauma exposure and frequency of religious service attendance. Note that only individuals who reported ever using cannabis in their lifetime were included in DSM-5 CUDsx analyses. All other individuals were classified as unknown and were not included in analyses of CUD symptoms. Sensitivity analyses including these individuals were conducted as well to examine the influence of excluding these individuals in our analyses. In addition, secondary models included cross-terms for all variables included in the interaction models (e.g., Model 2 included PRS × trauma, PRS
