previous CAD metaGRS21 in French-Canadian cohorts43 suggests that scores developed on the UK Biobank are generalisable to other cohorts of European ancestry. Our modelling assumes that risk factors, such as SBP and BMI, can be varied independently of each other. In practice, common lifestyle interventions such as exercise and diet will likely affect several risk factors at a time. Finally, this study focused on British white ancestry and it is yet unknown what performance is achievable in individuals of different ancestry;44 successful development of scores in non-Europeans will require both stroke GWAS summary statistics from non-Europeans as well as sufficiently large prospective studies of stroke on which to validate these scores.
