and waist-to-hip ratio (rG = 0.12, s.e = 0.02). Many of these genetic correlations are similar to those reported by Wray, et al. 9 and Howard, et al. 5, including earlier age at menarche (rG = -0.12, s.e = 0.02). However, a novel genetic correlation was observed for age at menopause (rG = -0.11, s.e. 0.03), potentially indicating a shared genetic architecture between depression and earlier female reproductive life events. Additionally, novel genetic correlations were observed between depression and Crohn’s disease (rG = 0.09, s.e. 0.03) and depression and an earlier age of smoking initiation (rG = -0.21, s.e. 0.06).
