As an additional exploratory analysis, we examined the associations of SNPs within 50kb of 24 previously reported candidate TS genes (Tables S6-S7). We found no excess of lower p-values among the 2135 SNPs within these genes compared to those expected under the null, suggesting that these candidate genes are not enriched for common SNPs associated with TS (Figure S16). One signal in the primary European ancestry meta-analysis had a nominal p<1 ×10−3 (rs10277969 within CNTNAP2, p=7.8 ×10−4), but this locus did not survive a Bonferroni correction for gene size (266 LD-independent SNPs within CNTNAP2, corrected p=.21).
