disorder and transcriptome data from the PredictDB Data Repository for 11 brain regions, liver tissue, whole blood, and two types of adipose tissue. We included these tissues because cannabis use disorder is a psychiatric disorder and tetrahydrocannabinol, a key psychoactive cannabis component, accumulates in adipose tissue.30 Analyses were restricted to the European ancestry meta-analysis because the prediction models were trained on reference transcriptome data from GTEx version 831 using only individuals of European ancestry. The significance threshold was corrected for the total number of gene-tissue pairs tested (75 684 tested, α=6·69 × 10−7).
