In this study, we calculated the AUD PGS using concordant SNVs and a 2-stage design. In the AOU and IB cohorts (which were not ascertained to study AUD), the top 5% with the highest PGS were 2 times more likely to develop AUD (ORs of 1.96 and 2.07) compared with the remaining 95%, whereas the risk was approximately half for the bottom 5% (ORs of 0.53 and 0.57). The PGS had similar estimabilities in both male and female individuals.
