We additionally investigated potential sharing of eQTLs identified by the CommonMind Consortium in the adult human brain [49] that have been implicated in schizophrenia or neuroticism in the SMR study of Hauberg and colleagues [45]. For this, we restricted our analyses to the fetal brain eGenes detected at FDR < 0.05 that overlapped with those implicated by Hauberg et al. in neuropsychiatric traits, and explored potential linkage disequilibrium between the top adult brain SMR eQTL and the most significant fetal brain eQTL for each gene. We report instances where the top adult brain SMR eQTL and the top eQTL for that gene in fetal brain have an r2 > 0.8 in our samples, suggesting shared causal variants.
