Chunk #7 — Results — European ancestry PTSD GWAS

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Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.

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The EA meta-analysis identified 81 independent genome-wide significant (GWS) loci, including 5 GWS loci on the X chromosome (Extended Data Fig. 2, Supplementary Figs. 1 and 2, Supplementary Table 6, regional association plots in Supplementary Data 1, forest plots in Supplementary Data 2, and Supplementary Note). Relative to recent prior PTSD GWAS, 67 loci are novel11–13 (Supplementary Table 7). No region exhibited significant effect size heterogeneity (Supplementary Fig. 3).