We tested the ability of five antipsychotic drugs to improve neuronal connectivity in vitro. Clozapine, Loxapine, Olanzapine, Risperidone and Thioridazine were administered for the final three weeks of neuronal differentiation. Only Loxapine significantly increased neuronal connectivity in hiPSC neurons from all patients (Fig. 2B; SI Fig. 5). Optimization of the concentration and timing of drug administration may improve the effects of the other antipsychotic medications.
