Initial and adaptive responses to alcohol were assessed using scalar indices of change (Morzorati et al., 2002; Ramchandani et al., 1999b). One index assessed “initial response” (improvements or impairments) in brain function after alcohol. The other index assessed “acute adaptation” (tolerance or sensitization) to alcohol while the brain’s exposure to alcohol was held constant. We defined initial response as the difference in the SS or the BAES between the baseline and the first 30 minutes after the beginning of the infusion. The index of acute adaptation was computed as the changes in the measurement of subjective responses from 30 minutes to 4 hours after the infusion by measuring every 30 minutes 8 times total as shown in Fig. 1.
