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Chunk #27 — METHODS — EVALUATION OF THE PROPOSED METHOD — NULL DISTRIBUTION OF THE P-VALUES OF THE CORRECTED χ2 TEST

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Case-control association testing in the presence of unknown relationships.
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In Scenario I, we evaluated whether resulting p-values were distributed uniformly as would be expected under the null distribution. The χ2 test and the corrected χ2 test with ϕact, ϕped, ϕest, and ϕpost were performed for each multiallelic marker and Q – Q plots were used to examine the uniformity of the p-value distributions. Note that the same markers are used for both the estimation of kinship coefficients in the previous section and for the test of association.