the 3′ end of the ANKK1 gene and was immediately downstream of the DRD2 gene, a target of all antipsychotic drugs. It is possible that this region could contain regulatory regions relevant to the dopamine D2 receptor function, and the functional effects of this CNV, as well as its presence in other cohorts, should be further investigated. It should be noted, however, that 1/1,547 cognitively normal subject in the extra control cohort also carried this deletion, so if it is a risk factor it has incomplete penetrance.
