no association between rs16966968 and SI or SC, age at SI, or age at SC. However, when cancer cases and controls were combined (after adjustment for case/control status), the adjusted mean difference between the two homozygote genotypes was 1.2 CPD (P<0.0001). Moreover, the rs16969968 genotype was associated with LC in both former (P<0.0001) and current (P<0.0001) smokers, and a marginally significant trend was observed in never smokers (P = 0.07).
