polymerase-1 (PARP-1) was shown to preferentially bind to the -172T allele and positively regulate OPRM1 gene expression (Ono et al. 2009a). Bioinformatics assessment suggests that C/EBP or CREB binds to the SNP -1748G>A region, OCT-1 binds to the SNP -1565T>C region and the SNP -1045A>G region, and GATA, MZF, and SP1 bind to the SNP -172G>T region (Ono et al. 2009b).
