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Chunk #19 — Methods — Application of creQTL to Endometrial Cancer

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Co-regulatory expression quantitative trait loci mapping: method and application to endometrial cancer.
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all three genotypes were seen. To enrich the microarray data for abundant and strongly-hybridized transcripts, we calculated the variance of each probe and excluded the lowest 50% from our analyses. Microarray data were ranked and normalized to mean 0 and variance 1/3 across each gene, the default for the Gene Recommender algorithm. SNP r2 values were calculated with 'snpMatrix.' Because all 52 samples were from a single county in Norway [27], we did not perform any adjustments for population stratification.