Supplementary Table 19b). The specific PPP6C variants nominally associated with OA in this gSEM GWAS have been associated with neuroticism, depressive symptoms and a number of smoking phenotypes at genome-wide significance (Supplementary Table 19b). Variants in FURIN have been associated with other brain- and SUD-related phenotypes, most predominantly schizophrenia, but also risk taking, number of sexual partners, and insomnia (Supplementary Fig. 20; Supplementary Table 19c). The variant driving the GWS gene-based result here (rs17514846) and the GWS variant in our subset meta-analysis for OA (rs11372849) are associated with each of these phenotypes at genome-wide significance (Supplementary Table 19c).
