We performed a two-stage analysis that initially focused on the 3′ SNP rs9804190 based on its prior association with both bipolar disorder and ankyrin G expression (Baum et al., 2008; Roussos et al., 2012; Schulze et al., 2009; Sklar et al., 2011), followed by examining each of the 358 genotyped SNPs with MAF > 5% within 5 kb of the chromosome 10 region encompassing all ankyrin G isoforms (NCBI nucleotide ID NM_001204403 from chr10: 61,786,056-62,493,284), including the brain-specific isoforms (Zhou et al., 1998) of particular interest based on the mouse model studies (Leussis et al., 2012a) (NM_020987.3 from chr10: 61,786,056-62,149,634). A 5′ region SNP that has also been associated with both bipolar disorder and ankyrin G expression in the brain, rs1938526 (Ferreira et al., 2008; Rueckert et al., 2012; Smith et al., 2009), was not genotyped in this cohort and therefore not analyzed. SNPs rs10994336 and rs10994397 in the 5′ region that had previously associated with bipolar disorder but not ankyrin G expression were tested in the second stage (Ferreira et al., 2008; Schulze et al., 2009; Scott et al.,
