Chunk #117 — III. Selected Methodological Issues — C. Analyses — 2. Stepwise approaches to analyses

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

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d) Identifying the clustered, nominally positive SNPs within the strongest positive support from several “generalization” datasets: To seek possible generalization of results, we have sought chromosomal locations where the clustered positive data from several substance-dependence genome wide association samples lies near clustered, nominally-positive (and reproducibly positive) results from studies from other “related, heritable” phenotypes.