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Chunk #29 — Results — fMRI — Group Effects

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Family history of alcoholism mediates the frontal response to alcoholic drink odors and alcohol in at-risk drinkers.
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However, there was a significant three-way Group × Odor × Condition interaction in the right mPFC ROI (F= 4.82, p < 0.05). As visualized in voxel-wise maps (Figure 5A) and in plots of the ROI means (Figure 5B), the interaction was such that under placebo, the HD-FHP had a significantly greater BOLD response to AO than to ApCO, while the same contrast within the HD-FHN was insignificant. Under alcohol, this differential odorant response became insignificant in the HD-FHP, but significant in the HD-FHN.