The number of hits at a certain threshold gives a guide to the ease of detection of genes contributing to the phenotype. The significance level of the individual association signals is also important. Broadly, the first issue relates to the number of loci of given effect size, whereas the second relates to whether some loci have particularly large effect sizes. We note that the strongest signal in the RDC schizoaffective disorder, bipolar type subset of participants was more significant than any hit in either the bipolar disorder set as a whole or the other subsets considered, which further supports the genetic utility of such cases.
