Biological pathway enrichment analyses carried out in ConsensusPathDB [44] using the genes implicated by the eQTL databases (Table 2) and/or a coding SNVs (i.e., PJA1, GPR101) showed that the (i) pyrimidine metabolism and (ii) activation of nicotinic acetylcholine receptors pathways are enriched for these smoking behaviour associated genes (false discovery rate <0.01; P < 0.0001).
