Chunk #26 — DISCUSSION

Source: Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice.
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In conclusion, although ethanol induction of CYP2A5 is CYP2E1-dependent, unlike CYP2E1, CYP2A5 protects against alcohol-induced oxidative stress and liver injury. CYP2A5 may participate in lipid metabolism, by inhibiting fat accumulation in liver and, consequently, inhibiting steatohepatitis.