Fig. 5A–C illustrates a grand mean S-transform time-frequency representation of the rare auditory oddball data in the frontal cortex obtained from HAP-1, LAP-1 and HS/Ibg mice. Visual inspection of the time-frequency representation of the EROs in Fig. 5A–C show changes in ERO energy following presentation of the rare tone. As shown in Fig. 5A–C, an increase in ERO energy in the delta, theta and alpha/beta frequency bands is observed following presentation of the rare tone (vs. baseline). Changes in ERO energy were also observed following presentation of standard and noise tones (data not shown). Differences in ERO energy among the three auditory stimuli were observed in the frontal and parietal cortices when collapsing across HAP-1, LAP-1 and HS/Ibg groups. Two-way repeated measures ANOVA with ERO energy as dependent variable revealed a significant main effect of Tone in the delta (0–50 ms, 50–350 ms and 350–800 ms time windows), theta (0–50 ms and 350–800 ms time windows) and alpha/beta (0–50 ms, 50–350 ms and 350–800 ms time windows) frequency bands in the frontal cortex (Table 3). Repeated measures ANOVA also showed
