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Chunk #27 — DISCUSSION

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Assessing the clinical meaningfulness of slowing CDR-SB progression with disease-modifying therapies for Alzheimer's disease.
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Despite the methodological limitations of our study, these findings can serve as a tool for understanding the relationship between the CDR‐SB and functional independence. Our hope is that this modeling can be used to describe the functional implications of AD dementia progression, regardless of whether amyloid‐lowering treatments are being considered. Furthermore, this work provides an approach to better understand the clinical meaningfulness of AD treatments in terms that patients and families may find more understandable.