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Chunk #27 — Results — Polygenic localization of 49 complex traits

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Functionally informed fine-mapping and polygenic localization of complex trait heritability.
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Our results demonstrate that half of the common SNP heritability of complex traits is causally explained by typically thousands of SNPs (median M50%=8.9K), and the remaining heritability is spread across an extremely large number of extremely weak-effect SNPs (median M95%=4.4 million), consistent with extremely polygenic but heavy-tailed trait architectures1,34–36,39–43.