PRS can also be used to test specific hypotheses; for example, PRS can be used to measure how environmental, demographic, and genetic factors interact with one another. Are there developmental windows where the effects of alcohol use and misuse are more invasive? Can we identify biomarkers that would inform the transition from normative alcohol use to excessive use and dependence? For instance, the alcohol metabolizing genetic effects on alcohol use appeared to be more influential in later years of college than in earlier years (55, 56), revealing that the nature and magnitude of genetic effects vary across development.
