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Chunk #15 — Materials and Methods — Operationalization of Variables — Childhood Adversity

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The joint effects of ADH1B variants and childhood adversity on alcohol related phenotypes in African-American and European-American women and men.
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Subjects were coded positive for exposure to childhood adversity if they responded “yes” to any of the following questions and negative if they did not: (1) “Did either of your parents die before you were age 6?” (2) “Did you ever witness or experience a violent crime, like a shooting or a rape, by age 13?” (3) “By the time you were age 13, were you ever sexually abused?”, or (4) “By the time you were age 13, were you ever beaten by an adult so badly that you needed medical care or had marks on your body that lasted for more than 30 days?”ADH1B Variant Groups For each SNP, we combined individuals with AA or AG genotype into a single group, that is A-allele carriers, and compared them to individuals with a GG genotype, that is noncarriers of the A allele.