Chunk #49 — Methods — Statistical methods. — Polygenic risk score calculation.

Source

Improving the trans-ancestry portability of polygenic risk scores by prioritizing variants in predicted cell-type-specific regulatory elements.

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yes

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We evaluated PRS performance using EAS individuals. First, we used all individuals in the BBJ cohort for PRS-EUR testing. Second, we compared the improvement afforded by IMPACT in PRS-EUR relative to PRS-EAS models using 5,000 randomly selected individuals in BBJ; specifically for case–control GWAS, we randomly selected 1,000 cases and 4,000 controls.