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Chunk #55 — Understanding MEA signals — MEA signal flow — Neuron-electrode interface

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Revealing neuronal function through microelectrode array recordings.
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“Fluid”-side: voltage at the electrode by volume conduction. For simple geometries of the “fluid”-side, assuming that the MEA surface is an insulating infinite plane and the fluid a homogenous, isotropic medium, we can apply the method of images to the point-source equation given in Section The extracellular space, such that the potential Ve at any given electrode e can be solved using the following equation (Obien et al., 2013: Ve=12πσ∑Inrn.