We obtained genome-wide genotype information for schizophrenia cases from the UK (the CLOZUK sample), which we combined with control datasets obtained from public repositories or through collaboration. The final sample size was 11,260 cases and 24,542 controls (5,220 cases and 18,823 controls not in previous schizophrenia GWAS; Methods and Supplementary Figs. 1 and 2). At a genome-wide level, the association statistics indicated that the common variant architecture in the CLOZUK sample was highly correlated with that in an independent sample of 29,415 cases and 40,101 controls from the PGC (genetic correlation = 0.954± 0.030; P = 6.63 × 10−227), and this was further confirmed by polygenic risk score and trend test analyses across the datasets at a range of association P-value thresholds (Methods and Supplementary Tables 1 and 2).
