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Chunk #18 — SUSCEPTIBILITY LOCI AND GENES OF COMPLEX NEURODEVELOPMENTAL DISORDERS — Bipolar Disorder

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Genetic and environmental factors in complex neurodevelopmental disorders.
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Bipolar disorder, also known as manic-depressive illness, is a severe mental disorder characterized by recurrent manic and depressive episodes causing dramatic mood swings. The prevalence of bipolar disorder is estimated to be 0.8-2.6% [21]. Although some have their first symptoms in childhood, most patients develop episodes in late adolescence or early adulthood. Bipolar disorder patients show many clinical features that are similar to those of schizophrenic patients, such as age of onset, psychotic symptoms, episodic courses of illness and a lifelong endurance. However, also clear distinctions exist between the two disorders. For example, bipolar disorder manifests as an impairment of mood, whereas schizophrenia is a primary disorder of cognition. Furthermore, most bipolar patients benefit from lithium therapy, whereas schizophrenics seldom do.